This inventive animated comedy series, set inside a giant fish tank in Bud's Pet Shop, presents high school life as seen through the eyes of three BFFs (best fish friends), Bea, Milo and Oscar. Together they experience the typical life challenges and triumphs, including friendship, dating and sports, along with more atypical situations such as giant lobster attacks and, with the use of special land suits, school field trips to the hamster cages. The series was created by children's book illustrator Noah Z. Jones and features a notable voice cast. It's produced using an innovative mixture of digital animation and photo collage
Bea wants her school photo to be perfect. When the photo turns out horrible, she enlists her friends Milo and Oscar to help her retrieve it and get rid of it.
Bea has a girl sleepover party and Milo and Oscar feel left out, so attend the party as Milina and Oscerlisabeth. Chelsea and Bea let the other girls know that they are Milo and Oscar. But instead of confronting them, the girls then make them do what girls really do on sleepover parties.
Milo ventures out of the fish tank alone, so Bea and Oscar follow him. The three best friends catch the eye of the pet store cat Wilfred, and Milo must put aside his differences with the others to save the day.
When Bea goes on several dates and Milo gets a date, Oscar feels he is the only one without a girl so and pretends to have a girlfriend named Doris Flores Gorgeous, but he struggles to keep it a secret from Milo and Bea. He tells Milo and Bea that Doris lives in Fish Niagara Falls so the friends try to "cheer up" Oscar by taking him there. When they get there, there actually is Doris who turned out to be Clamantha.
Milo tries to follow his dream by playing on the Football team but gets the job of Water Boy. Little does he realize the importance of his job, since the football team is playing at the Gecko tank.
When Jocktopus's birthday comes up, he warns every student in freshwater high that if they don't bring a gift for him, they will get "pounded" by him. When shopping for said gift Oscar suggests getting him money, which results in Oscar himself being given as a gift by his friends who don't want to be pounded. Bea and Milo try to get him back.